Modeling of small radiation doses on the elastic characteristics of DNA

Authors

  • Andrey N. Kamlyuk State Educational Establishment «Institute for Command Engineers» of the Ministry of Emergency Situations of the Republic of Belarus; 220118, Belarus, Minsk, ul. Mashinostroiteley, 25 https://orcid.org/0000-0002-9347-0778
  • Aleksey V. Shirko Belarusian State Technological University; 220006, Belarus, Minsk, ul. Sverdlova, 13A
  • Il'ya S. Zhavoronkov State Educational Establishment «Institute for Command Engineers» of the Ministry of Emergency Situations of the Republic of Belarus; 220118, Belarus, Minsk, ul. Mashinostroiteley, 25

Keywords:

low dose, single-stranded break, comparison of the theory with experiment

Abstract

The effect of small doses of radiation on human an example DNA molecule is considered. Proposed and studied the linear model of the DNA molecule in a viscous environment with the help of the Lagrange equations. The calculated values are obtained for the DNA molecule breaks by small doses of radiation. A comparison was made the theory with experiment. The results obtained can be used to predict the effects of small doses of radiation on the DNA molecule and the human body as a whole.

Author Biographies

Andrey N. Kamlyuk, State Educational Establishment «Institute for Command Engineers» of the Ministry of Emergency Situations of the Republic of Belarus; 220118, Belarus, Minsk, ul. Mashinostroiteley, 25

PhD in Physical and Mathematical Sciences, Associate Professor

Aleksey V. Shirko, Belarusian State Technological University; 220006, Belarus, Minsk, ul. Sverdlova, 13A

PhD in Physical and Mathematical Sciences

References

Rube, C.E. DNA double-strand break rejoining in complex normal tissues / C.E. Rube, X. Dong, M. Kühne et al. // Int. J. Radiat. Oncol. Biol. Phys. – 2008. – V. 72, № 28. – P. 1180–1187.

Rothkamm, K. Evidence for lack of DNA double-strand break repair in human cells exposed to very low x-ray doses / K. Rothkamm, M. Lobrich // Proc. Natl. Acad. Sci. U.S.A. – 2003. – V. 100, № 9. – P. 5057-5062.

Жижина, Г.П. Влияние малых доз низкоинтенсивной ионизирующей радиации на структуру и функции ДНК / Г.П. Жижина // Радиационная биология. Радиоэкология. – 2011.–Т. 51, № 2. – С. 218-228.

Осипов, А.Н. Индукция и репарация двунитевых разрывов ДНК в лимфоцитах крови человека, облученных в адаптирующей дозе / А.Н. Осипов, Е.Ю. Лизунова, Н.Ю. Воробьева, И.И. Пелевина // Радиационная биология. Радиоэкология. – 2009. – Т. 49, № 1.– С. 42-45.

Zdravkovic, S. Single molecule unzippering experiments on DNA and Peyrard-Bishop-dauxois model / S. Zdravkovic, M. Sataric // Phys. Rev. E. – 2006. – V. 73, P. 1–11.

Lee, G.U. Direct measurement of the forces between complementary strands of DNA / G.U. Lee, L.A. Chrisey, R.J. Colton // Science. – 1994. – V. 266, P. 771–773.

Phillips Kevin G. Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope/ Kevin G. Phillips, L. Jacques Steven, J.T. McCarty Owen // Phys. Rev. Lett. – 2012. – V.109, P. 105-118.

Downloads


Abstract views: 113
PDF Downloads: 31

Published

2014-08-12

How to Cite

Kamlyuk А., Shirko А. and Zhavoronkov И. (2014) “Modeling of small radiation doses on the elastic characteristics of DNA”, Vestnik of the Institute for Command Engineers of the MES of the Republic of Belarus, 20(2), pp. 49–52. Available at: https://journals.ucp.by/index.php/vice/article/view/485 (Accessed: 3 July 2024).

Most read articles by the same author(s)

1 2 > >>