Modeling of small radiation doses on the elastic characteristics of DNA
Keywords:
low dose, single-stranded break, comparison of the theory with experimentAbstract
The effect of small doses of radiation on human an example DNA molecule is considered. Proposed and studied the linear model of the DNA molecule in a viscous environment with the help of the Lagrange equations. The calculated values are obtained for the DNA molecule breaks by small doses of radiation. A comparison was made the theory with experiment. The results obtained can be used to predict the effects of small doses of radiation on the DNA molecule and the human body as a whole.
References
Rube, C.E. DNA double-strand break rejoining in complex normal tissues / C.E. Rube, X. Dong, M. Kühne et al. // Int. J. Radiat. Oncol. Biol. Phys. – 2008. – V. 72, № 28. – P. 1180–1187.
Rothkamm, K. Evidence for lack of DNA double-strand break repair in human cells exposed to very low x-ray doses / K. Rothkamm, M. Lobrich // Proc. Natl. Acad. Sci. U.S.A. – 2003. – V. 100, № 9. – P. 5057-5062.
Жижина, Г.П. Влияние малых доз низкоинтенсивной ионизирующей радиации на структуру и функции ДНК / Г.П. Жижина // Радиационная биология. Радиоэкология. – 2011.–Т. 51, № 2. – С. 218-228.
Осипов, А.Н. Индукция и репарация двунитевых разрывов ДНК в лимфоцитах крови человека, облученных в адаптирующей дозе / А.Н. Осипов, Е.Ю. Лизунова, Н.Ю. Воробьева, И.И. Пелевина // Радиационная биология. Радиоэкология. – 2009. – Т. 49, № 1.– С. 42-45.
Zdravkovic, S. Single molecule unzippering experiments on DNA and Peyrard-Bishop-dauxois model / S. Zdravkovic, M. Sataric // Phys. Rev. E. – 2006. – V. 73, P. 1–11.
Lee, G.U. Direct measurement of the forces between complementary strands of DNA / G.U. Lee, L.A. Chrisey, R.J. Colton // Science. – 1994. – V. 266, P. 771–773.
Phillips Kevin G. Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope/ Kevin G. Phillips, L. Jacques Steven, J.T. McCarty Owen // Phys. Rev. Lett. – 2012. – V.109, P. 105-118.
Published
How to Cite
License
Copyright (c) 2014 Kamlyuk A.N., Shirko A.V., Zhavoronkov I.S.CC «Attribution-NonCommercial» («Атрибуция — Некоммерческое использование») 4.0